Cancer BiologybioRxiv
Suppression of HSF1 activity by wildtype p53 creates the driving force for p53 loss-of-heterozygosity, enabling mutant p53 stabilization and invasion
O. C. Sener, A. Stender, L. Klemke…·R. Schulz-Heddergott
This paper identifies the WTp53-HSF1 axis as the driver of p53LOH in colorectal tumors, enabling mutp53 stabilization and invasion.