O. Hofnagel

This study determines the cryo-EM structure of Mcf1 toxin and elucidates its activation mechanism through conformational changes and autocleavage.

This study identifies a molecular backdoor mechanism for inorganic phosphate release from actin filaments, showing how a disease-linked mutation alters Pi release rates and filament structure.

The paper reports structures of TRPC4 in complex with inhibitors, activators, and calmodulin, revealing how ligand binding and calmodulin interaction regulate the channel's conformation.

The paper reports the cryo-EM structure of zebrafish TRPC4 in its closed, unliganded state, revealing key structural features and insights into its function and pharmacology.