O. L. Griffith

Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer

Genomic and transcriptomic somatic alterations of hepatocellular carcinoma in non-cirrhotic livers

This study identifies genomic and transcriptomic alterations in non-cirrhotic hepatocellular carcinoma, revealing recurrent mutations and structural variants that may contribute to tumorigenesis.

p53 mutations exhibit sex specific gain-of-function activity in gliomagenesis

This study identifies sex-specific gain-of-function activity of p53 mutations in glioblastoma, showing mutation-specific differences in transforming astrocytes and altering gene expression patterns.

Comparative Multiomic Analysis Reveals Low T Cell Infiltration as the Primary Feature of Tobacco Use in HPV(+) Oropharyngeal Cancer

This study identifies low T cell infiltration as a key feature of tobacco use in HPV-positive oropharyngeal cancer, linked to worse outcomes.

Stool-derived eukaryotic RNA biomarkers for detection of high-risk adenomas

This study develops a stool-derived eukaryotic RNA biomarker model to detect high-risk adenomas and early-stage CRC with high sensitivity and specificity.

Spontaneous aggressive ERα+ mammary tumor model is driven by Kras activation

This study identifies Kras activation as a driver of spontaneous ERα+ mammary tumors in a murine model, validated through genomic and transcriptomic analyses.