Author

M. Griffith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 8 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 8 Research Focus:cell type annotation· 6 Organism:human· 6 Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 4 Approach:statistical model· 4 Organism:mouse· 3

Frequent Co-Authors

O. L. Griffith· 6 shared Z. L. Skidmore· 4 shared E. K. Barnell· 3 shared K. Krysiak· 2 shared K. M. Campbell· 2 shared O. Griffith· 2 shared A. A. Chaudhuri· 1 shared A. Adonyi· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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6 shared papersCancer Biology

O. L. Griffith

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Single-Cell Transcriptomic Analysis of Kaposi Sarcoma

D. A. Rauch, P. Valino Ramos, M. Khanfar, J. Harding, A. Joseph, O. Griffith, M. Griffith, L. Ratner

This study uses single-cell RNA sequencing to analyze Kaposi Sarcoma tumors and blood samples, identifying KSHV-infected cell types and their biomarkers, and showing changes with therapy.

bioRxiv · May 1, 2024Cancer Biology

Sub-retinal transplantation of human iPSC-derived retinal sheets: A promising approach for the treatment of macular degeneration

A. Barabino, K. Mellal, R. Hamam, A. Polosa, M. Griffith, J.-F. Bouchard, A. Kalevar, R. Hanna, G. Bernier

This study demonstrates the potential of human iPSC-derived retinal sheets for treating macular degeneration by showing their integration and functional responsiveness in a porcine model.

bioRxiv · Oct 19, 2023 · PreprintBioengineering

Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer

S. L. Freshour, T. H.-P. Chen, B. Fisk, H. Shen, M. Mosior, Z. L. Skidmore, C. Fronick, J. K. Bolzenius, O. L. Griffith, V. K. Arora, M. Griffith

bioRxiv · Mar 28, 2023Cancer Biology

Autologous humanized PDX modeling for immuno-oncology recapitulates the human tumor microenvironment

M. Chiorazzi, J. Martinek, B. Krasnick, Y. Zheng, K. J. Robbins, R. Qu, G. Kaufmann, Z. Skidmore, L. A. Henze, F. Brosecke, A. Adonyi, J. Zhao, L. Shan, E. Sefik, J. Mudd, , R. A. Flavell

This study develops an autologous humanized PDX model to study tumor-immune interactions and demonstrates its utility in preclinical testing by showing VEGF-A inhibition reduces tumor growth.

bioRxiv · Aug 19, 2022 · PreprintCancer Biology

Genomic and transcriptomic somatic alterations of hepatocellular carcinoma in non-cirrhotic livers

Z. L. Skidmore, J. Kunisaki, Y. Lin, K. C. Cotto, E. K. Barnell, J. Hundal, K. Krysiak, V. Magrini, L. Trani, J. R. Walker, R. Fulton, E. Brunt, C. A. Miller, R. K. Wilson, E. R. Mardis, , O. L. Griffith

This study identifies genomic and transcriptomic alterations in non-cirrhotic hepatocellular carcinoma, revealing recurrent mutations and structural variants that may contribute to tumorigenesis.

bioRxiv · Dec 14, 2021Cancer Biology

p53 mutations exhibit sex specific gain-of-function activity in gliomagenesis

N. C. Rockwell, W. Yang, N. Warrington, M. Griffith, O. L. Griffith, C. Gurnett, B. Cohen, D. Baldridge, J. B. Rubin

This study identifies sex-specific gain-of-function activity of p53 mutations in glioblastoma, showing mutation-specific differences in transforming astrocytes and altering gene expression patterns.

bioRxiv · Jun 11, 2021 · PreprintCancer Biology

Comparative Multiomic Analysis Reveals Low T Cell Infiltration as the Primary Feature of Tobacco Use in HPV(+) Oropharyngeal Cancer

B. M. Wahle, P. Zolkind, R. Ramirez, Z. L. Skidmore, A. Mazul, D. N. Hayes, V. C. Sandulache, W. L. Thorstad, D. Adkins, O. L. Griffith, M. Griffith, J. P. Zevallos

This study identifies low T cell infiltration as a key feature of tobacco use in HPV-positive oropharyngeal cancer, linked to worse outcomes.

bioRxiv · Mar 23, 2021 · PreprintCancer Biology

Stool-derived eukaryotic RNA biomarkers for detection of high-risk adenomas

E. K. Barnell, Y. Kang, A. R. Barnell, K. M. Campbell, K. R. Kruse, E. M. Wurtzler, M. Griffith, A. A. Chaudhuri, O. L. Griffith

This study develops a stool-derived eukaryotic RNA biomarker model to detect high-risk adenomas and early-stage CRC with high sensitivity and specificity.

bioRxiv · Jan 29, 2019Cancer Biology

Spontaneous aggressive ERα+ mammary tumor model is driven by Kras activation

K. M. Campbell, K. A. O'Leary, D. E. Rugowski, W. A. Mulligan, E. K. Barnell, Z. L. Skidmore, K. Krysiak, M. Griffith, L. A. Schuler, O. L. Griffith

This study identifies Kras activation as a driver of spontaneous ERα+ mammary tumors in a murine model, validated through genomic and transcriptomic analyses.

bioRxiv · Oct 16, 2018Cancer Biology