P. Guo

Y chromosome linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues

The paper investigates how UTY modulates sex-specific methylation in male valvular fibroblasts in response to nanoscale extracellular matrix cues, promoting osteoblast-like cell phenotypes in aortic valve stenosis.

Combined Partial-Nitrification and Phosphorus Removal with the co-existence of Nitrite-resistant phosphorous accumulating organisms (PAOs) and nitrifiers in the treatment of high-strength manure digestate

This study demonstrates the coexistence of nitrite-resistant PAOs and nitrifiers in a reactor treating manure digestate, achieving efficient nitrogen and phosphorus removal through optimized aeration schemes.

Rapid Development of a Mucosal Nanoparticle Flu Vaccine by Genetic Engineering of Bacteriophage T4 using CRISPR-Cas

This study develops a mucosal nanoparticle flu vaccine using CRISPR-Cas to engineer bacteriophage T4, showing it induces both mucosal and systemic immunity in mice.

RFC1 AAGGG pentanucleotide repeats form parallel G-quadruplex: structural implications for aberrant molecular cascades in CANVAS

The paper identifies and structures the G-quadruplex formed by RFC1 AAGGG repeats, showing its role in replication stalling and transcription inhibition in CANVAS.

Spatial transcriptomic atlas of shoot organogenesis in tomato callus

This study creates a spatial transcriptomic atlas of tomato callus during shoot regeneration, identifying cell types and developmental trajectories.

A Methylation-Phosphorylation Switch Controls EZH2 Stability and Hematopoiesis

The paper identifies a methylation-phosphorylation switch regulating EZH2 stability and hematopoiesis through AKT-mediated phosphorylation of EZH2.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

Bacteriophage T4 Vaccine Platform for Next-generation Influenza Vaccine Development

This study demonstrates a T4 phage-based vaccine platform that incorporates M2e antigens, showing high immunogenicity and complete protection against influenza without adjuvants.

An integrative structural model of the full-length gp16 ATPase in bacteriophage phi29 DNA packaging motor

This study reports the crystal structure of gp16-CTD and simulations of the full-length gp16, revealing its role in dsDNA packaging through interactions with pRNA and dynamic domain interplay, refining the inchworm-revolution model.

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

Doxycycline has Distinct Apicoplast-Specific Mechanisms of Antimalarial Activity

This study shows doxycycline kills malaria parasites via apicoplast-specific mechanisms at high concentrations, with distinct metal-dependent and delayed-death effects in different cycles.

In situ Fucosylation for Modulating Wnt Signaling in Live Cells

This study shows that fucosylation of N-glycans modulates Wnt signaling by affecting LRP6 endocytosis, revealing a new glycosylation-dependent regulatory mechanism.

A triple-hybrid cross reveals a new hybrid incompatibility locus between D. melanogaster and D. sechellia

The paper identifies two specific loci responsible for hybrid incompatibility between D. melanogaster and D. sechellia using a triple-hybrid cross and whole genome sequencing.

Apigenin relaxes rat intrarenal arteries: involvement of Cl- channels and K+ channels

This study shows apigenin relaxes rat intrarenal arteries by modulating Cl- and K+ channels, with effects mediated through CaCCs and Kv channels.