Mechanism of negative regulation of NF-κB by N4BP1
H. Shi, L. Sun, Y. Wang, A. Liu, X. Zhan, X. Li, M. Tang, P. Anderton, S. Hildebrand, J. Quan, S. Ludwig, E. M. Y. Moresco, B. Beutler
This study identifies N4BP1 as an inhibitor of NF-κB activation by interacting with NEMO, and shows that caspase 8 cleavage inactivates N4BP1 during TRIF-dependent signaling.
bioRxiv · Oct 21, 2020 · PreprintImmunology