Author

J. Quan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Approach:deep learning· 2 Organism:human· 2 Assay:metagenomics· 2 Organism:mouse· 2 Research Focus:variant calling· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. Langelier· 3 shared E. D. Crawford· 3 shared R. Sit· 3 shared S. Caldera· 3 shared A. Lyden· 2 shared A. McGeever· 2 shared B. Dimitrov· 2 shared M. Tan· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

C. Langelier

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Bovine milk glycoproteins inhibit SARS-CoV-2 and influenza virus co-infection

H. Yu, W. Chen, J. Shu, X. Wu, J. Quan, H. Cheng, X. Bao, D. Wu, X. Wang, Z. Li

This study shows that galactosylated glycoproteins from bovine milk inhibit both SARS-CoV-2 and influenza virus by blocking their interaction with ACE2.

bioRxiv · Feb 20, 2023 · PreprintMicrobiology

Mechanism of negative regulation of NF-κB by N4BP1

H. Shi, L. Sun, Y. Wang, A. Liu, X. Zhan, X. Li, M. Tang, P. Anderton, S. Hildebrand, J. Quan, S. Ludwig, E. M. Y. Moresco, B. Beutler

This study identifies N4BP1 as an inhibitor of NF-κB activation by interacting with NEMO, and shows that caspase 8 cleavage inactivates N4BP1 during TRIF-dependent signaling.

bioRxiv · Oct 21, 2020 · PreprintImmunology

Designing and implementing programmable depletion in sequencing libraries with DASHit

D. Dynerman, A. Lyden, J. Quan, S. Caldera, A. McGeever, B. Dimitrov, R. King, G. Cirola, M. Tan, R. Sit, M. van den Berge, H. A. M. Kerstjens, A. Faiz, S. Christenson, C. Langelier, , E. D. Crawford

The paper introduces DASHit, a software tool that designs CRISPR-based depletion targets to reduce high-abundance sequences in sequencing libraries, demonstrating its effectiveness across three species.

bioRxiv · Jan 12, 2020 · PreprintMicrobiology

Investigating Transfusion-Related Sepsis using Culture-Independent Metagenomic Sequencing

E. D. Crawford, J. Kamm, S. Miller, L. Li, S. Caldera, A. D. Lyden, D. Yokoe, A. Nichols, N. K. Tran, S. Barnhard, P. M. Conner, A. Nambiar, M. S. Zinter, M. Moayeri, P. Hayakawa Serpa, , C. Langelier

This study uses metagenomic sequencing to identify pathogens in transfusion-related sepsis cases, revealing a novel Acinetobacter species and demonstrating the utility of culture-independent methods.

bioRxiv · Sep 16, 2019Microbiology

FLASH: A next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences

J. Quan, C. Langelier, A. Kuchta, J. Batson, N. Teyssier, A. Lyden, S. Caldera, A. McGeever, B. Dimitrov, R. King, J. Wilheim, M. Murphy, L. Pesce Ares, K. A. Travisano, R. Sit, , E. D. Crawford

FLASH is a CRISPR-based diagnostic method that enhances detection of low-abundance antimicrobial resistance sequences in metagenomic data.

bioRxiv · May 12, 2019Microbiology