Author

B. Beutler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Liu· 2 shared E. M. Y. Moresco· 2 shared H. Shi· 2 shared S. Hildebrand· 2 shared A.-P. Foray· 1 shared C. H. Bu· 1 shared C. Marquet· 1 shared C. Pecquet· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

A. Liu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity.

E. Nair-Gill, J. Russell, L. Chen, A. Liu, J. Wang, S. Ghosh, X. Zhong, H. Shi, B. Beutler

This study identifies Lrp10 as a negative regulator of CD8 T cell homeostasis and tumor resistance by suppressing IL7R levels and enhancing anti-tumor immunity.

bioRxiv · Dec 8, 2023Immunology

De novo germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice

A.-P. Foray, S. Candon, S. Hildebrand, C. Marquet, F. Valette, C. Pecquet, S. Lemoine, F. Langa-Vives, M. Dumas, P. Hu, P. Santamaria, S. Lyon, L. Scott, C. H. Bu, T. Wang, , L. Chatenoud

This study identifies a de novo germline mutation in Dusp10 that accelerates autoimmune diabetes in NOD mice by increasing susceptibility through CRISPR validation and PD-L1 expression analysis.

bioRxiv · Dec 30, 2020 · PreprintImmunology

Mechanism of negative regulation of NF-κB by N4BP1

H. Shi, L. Sun, Y. Wang, A. Liu, X. Zhan, X. Li, M. Tang, P. Anderton, S. Hildebrand, J. Quan, S. Ludwig, E. M. Y. Moresco, B. Beutler

This study identifies N4BP1 as an inhibitor of NF-κB activation by interacting with NEMO, and shows that caspase 8 cleavage inactivates N4BP1 during TRIF-dependent signaling.

bioRxiv · Oct 21, 2020 · PreprintImmunology