F. Sanchez-Madrid

Phosphatases of regenerating liver balance F-actin rearrangements during T cell activation through WD repeat containing protein 1

This study shows that PRLs regulate F-actin dynamics during T cell activation by interacting with WDR1, affecting IS formation and cytokine production.

Allergic inflammation triggers dyslipidemia via IgG signalling

This study shows that IgG-mediated allergic inflammation increases serum triglycerides and alters lipid metabolism in mice and humans.

ART duration and immunometabolic state determine efficacy of DC-based treatment restoring functional HIV- specific CD8+ T cells in PLWH.

This study shows that ART duration affects CD8+ T cell function in HIV-1 patients, with longer ART improving DC-based immunotherapy outcomes through specific immunometabolic changes.

TAILORED DC INDUCE PROTECTIVE HIV-1 SPECIFIC POLYFUNCTIONAL CD8+ T CELLS IN THE LYMPHOID TISSUE FROM HUMANIZED BLT MICE

This study shows that TBK1-primed dendritic cells reduce HIV-1 disease progression in humanized mice by enhancing CD8+ T cell responses.

Synthetic antigen presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses.

This study uses synthetic antigen-presenting cells to analyze the composition and functional specialization of extracellular vesicles released during T cell immunological synapses.

Impaired miRNA degradation by post-transcriptional addition of 3' cytosine and adenine in T cell activation

The paper identifies post-transcriptional modifications in miRNAs during T cell activation, showing that 3' cytosine and adenine additions protect miRNAs from degradation.