P. D. Lee

Cryogenic non-invasive 3D X-ray phase-contrast imaging of unfixed, intact mouse joints reveals shifting chondrocyte hypertrophy across the endochondral interface

This study uses cryogenic X-ray phase-contrast imaging to analyze cartilage thickness and chondrocyte morphology in mouse joints, revealing differences between osteoarthritis-prone and healthy strains.

Multidimensional Analysis of the Adult Human Heart in Health and Disease using Hierarchical Phase-Contrast Tomography (HiP-CT)

This paper demonstrates HiP-CT's ability to image adult human hearts at multiple scales, revealing structural details in health and disease.

Mapping the blood vasculature in an intact human kidney using hierarchical phase-contrast tomography

This study maps the entire human kidney vasculature using hierarchical phase-contrast tomography, revealing structural differences in vascular architecture across kidney zones.

A closer look at high-energy X-ray-induced bubble formation during soft tissue imaging

This study investigates X-ray-induced bubble formation in soft tissues using combined imaging and gas analysis, showing vacuum degassing delays bubble nucleation and reveals dose-controlled growth mechanisms.

Preparation of large biological samples for high-resolution, hierarchical, multi-modal imaging

This paper describes a protocol for preparing large biological samples for high-resolution X-ray microtomography, improving contrast and reducing motion and bubble formation.

A multiscale X-ray phase-contrast tomography dataset of whole human left lung

The paper presents a high-resolution X-ray tomography dataset of a whole human left lung, capturing multiscale anatomical details from macroscopic to microscopic levels.

Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography

This paper introduces HiP-CT, a technique for high-resolution 3D imaging of intact human organs, and demonstrates its application to study structural details of organs and their functional units.