C. Walsh

Reconstructing microvascular network skeletons from 3D images: what is the ground truth?

This paper evaluates skeletonisation algorithms for 3D vascular networks, introducing a super-metric to assess and optimize their performance across different datasets.

tUbe net: a generalisable deep learning tool for 3D vessel segmentation

tUbe net is a deep learning tool for 3D vessel segmentation that can be generalized across tissues, modalities, and pathologies with minimal labeled data.

Physics-informed deep generative learning for quantitative assessment of the retina

This paper introduces a physics-informed GAN to generate realistic retinal blood vessel models, outperforming human labeling in segmentation and reconstruction.

Simultaneous Knockouts of the Oxytocin and Vasopressin 1b Receptors in Hippocampal CA2 Impair Social Memory

This study shows that simultaneous knockout of Oxtr and Avpr1b in hippocampal CA2 impairs social memory, with specific deficits in habituation and discrimination tasks.

STING-dependent cytosolic DNA sensing pathway drives the progression to leukemia in TET2-mutated HSPCs

This study shows that TET2 mutations cause DNA damage, activating the cGAS-STING pathway, which drives clonal hematopoiesis and leukemia, and that STING inhibition can suppress these effects in mouse and patient models.

A three-dimensional, discrete-continuum model of blood pressure in microvascular networks

The paper develops a 3D discrete-continuum model to simulate blood pressure in microvascular tissues without known capillary architecture, validated using mouse brain vascular network data.

Three-dimensional imaging and single-cell transcriptomics of the human kidney implicate perturbation of lymphatics in alloimmunity

This study uses 3D imaging and single-cell RNA-sequencing to analyze human kidney lymphatics, revealing structural and transcriptional changes in rejecting kidney transplants.

Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography

This paper introduces HiP-CT, a technique for high-resolution 3D imaging of intact human organs, and demonstrates its application to study structural details of organs and their functional units.

Multi-fluorescence high-resolution episcopic microscopy (MF-HREM) for three dimensional imaging of adult murine organs

This paper introduces MF-HREM, a 3D imaging technique for large biological samples, enabling multi-fluorescent staining and quantification in various biological contexts.

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

This study identifies unique molecular features of MDSCs using single-cell transcriptomics, revealing a distinct maturation trajectory and novel surface markers for their detection.