Author

N. Holroyd

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 2 Evolutionary Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Research Focus:differential expression· 4 Organism:mouse· 4 Organism:human· 3 Assay:imaging· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2

Frequent Co-Authors

C. Walsh· 4 shared S. Walker-Samuel· 4 shared M. Berriman· 3 shared C. Brandt· 2 shared C. McCarthy· 2 shared D. A. Long· 2 shared D. J. Jafree· 2 shared G. Rinaldi· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersBiophysics

C. Walsh

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Physics-informed deep generative learning for quantitative assessment of the retina

E. Brown, A. Guy, N. Holroyd, P. Sweeney, L. Gourmet, H. Coleman, C. Walsh, A. Markaki, R. Shipley, R. Rajendram, S. Walker-Samuel

This paper introduces a physics-informed GAN to generate realistic retinal blood vessel models, outperforming human labeling in segmentation and reconstruction.

bioRxiv · Jul 10, 2023Biophysics

A drug repurposing screen for whipworms informed by comparative genomics

A. Coghlan, F. A. Partridge, M. A. Duque-Correa, G. Rinaldi, S. Clare, L. Seymour, C. Brandt, T. T. Mkandawire, C. McCarthy, N. Holroyd, M. Nick, A. E. Brown, S. Tonitiwong, D. B. Sattelle, M. Berriman

This paper identifies potential anti-whipworm drugs by testing approved human drugs ex vivo and in vivo, finding limited efficacy due to pharmacokinetic challenges.

bioRxiv · Mar 2, 2023Pharmacology & Toxicology

Three-dimensional imaging and single-cell transcriptomics of the human kidney implicate perturbation of lymphatics in alloimmunity

D. J. Jafree, B. Stewart, M. Kolatsi-Joannou, B. Davis, H. Mitchell, L. G. Russell, L. Marinas del Rey, W. J. Mason, B. I. Lee, L. Heptinstall, G. Pomeranz, D. Moulding, L. Wilson, T. Wickenden, S. Malik, , D. A. Long

This study uses 3D imaging and single-cell RNA-sequencing to analyze human kidney lymphatics, revealing structural and transcriptional changes in rejecting kidney transplants.

bioRxiv · Oct 28, 2022 · PreprintImmunology

Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography

C. Walsh, P. Tafforeau, W. L. Wagner, D. J. Jafree, A. Bellier, C. Werlein, M. P. Kühnel, E. Boller, S. Walker-Samuel, J. L. Robertus, D. A. Long, J. Jacob, S. Marussi, E. E. Brown, N. Holroyd, , P. D. Lee

This paper introduces HiP-CT, a technique for high-resolution 3D imaging of intact human organs, and demonstrates its application to study structural details of organs and their functional units.

bioRxiv · Feb 3, 2021Physiology

Defining the early stages of intestinal colonisation by whipworms

M. A. Duque Correa, D. Goulding, F. Rodgers, C. Cormie, K. A. Rawlinson, A. Gillis, A. J. Bancroft, H. M. Bennett, M. Lotkowska, A. J. Reid, A. O. Speak, P. Scott, N. Redshaw, C. McCarthy, C. Brandt, , M. Berriman

This study investigates whipworm invasion of the intestinal epithelium using mouse models and single-cell RNA sequencing, revealing host-parasite interactions and immune responses.

bioRxiv · Aug 21, 2020Immunology

Strongyle-resistant sheep express their potential across environments and leave limited scope for parasite plasticity

G. Salle, V. Deiss, C. Marquis, G. Tosser-Klopp, J. Cortet, D. Serreau, C. Koch, D. Marcon, F. Bouvier, P. Jacquiet, N. Holroyd, A. Blanchard, J. Cotton, M.-M. Mialon, C. Moreno-Romieux

The paper breeds sheep resistant to parasites and finds that resistance remains stable across environments but is affected by specific parasite infections.

bioRxiv · Jun 19, 2020 · PreprintEvolutionary Biology

Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian development

M. Berriman, A. Wangwiwatsin, A. V. Protasio, S. Wilson, C. Owusu, N. Holroyd, M. Sanders, J. Keane, M. Doenhoff, G. Rinaldi

This study analyzes RNA-seq data from Schistosoma mansoni during intra-mammalian development, identifying genes involved in immune evasion and adaptation to oxidative stress.

PLOS Neglected Tropical Diseases · May 6, 2020Peer-reviewedMicrobiology

Multi-fluorescence high-resolution episcopic microscopy (MF-HREM) for three dimensional imaging of adult murine organs

C. Walsh, N. Holroyd, E. Finnerty, S. G. Ryan, P. W. Sweeney, R. J. Shipley, S. Walker-Samuel

This paper introduces MF-HREM, a 3D imaging technique for large biological samples, enabling multi-fluorescent staining and quantification in various biological contexts.

bioRxiv · Apr 3, 2020Biophysics