C. Werlein

Aberrant and Ectopic Cell Populations of the Fibrotic Pushing Border in Restrictive Allograft Syndrome after Lung Transplantation

This study identifies aberrant cell populations in RAS lungs using snRNA-seq and histology, revealing a fibrotic niche composed of specific cell types with potential therapeutic targets.

Multidimensional Analysis of the Adult Human Heart in Health and Disease using Hierarchical Phase-Contrast Tomography (HiP-CT)

This paper demonstrates HiP-CT's ability to image adult human hearts at multiple scales, revealing structural details in health and disease.

Preparation of large biological samples for high-resolution, hierarchical, multi-modal imaging

This paper describes a protocol for preparing large biological samples for high-resolution X-ray microtomography, improving contrast and reducing motion and bubble formation.

Ex Vivo Validation of Six FDA-Approved Non-Receptor Tyrosine Kinase Inhibitors (NRTKIs) as Antivirals to Pandemic and Seasonal Influenza A Viruses

The paper tests six FDA-approved non-receptor tyrosine kinase inhibitors for antiviral activity against influenza A viruses in cell cultures and human lung slices, finding potent inhibition of virus replication.

3D virtual Histopathology of Cardiac Tissue from Covid-19 Patients based on Phase-Contrast X-ray Tomography

This study uses phase-contrast x-ray tomography to analyze 3D cardiac tissue structure from Covid-19 patients, revealing distinct vascular changes compared to other viral myocarditides.

Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography

This paper introduces HiP-CT, a technique for high-resolution 3D imaging of intact human organs, and demonstrates its application to study structural details of organs and their functional units.