P. Dedon

Phosphorothioate DNA modification by BREX Type 4 systems in the human gut microbiome

The paper identifies new phosphorothioate DNA modification systems in the human gut microbiome using genomic and mass spectrometric analysis.

PT-seq: A method for metagenomic analysis of phosphorothioate epigenetics in complex microbial communities

PT-seq is a high-sensitivity method for mapping phosphorothioate DNA modifications in complex microbial communities and metagenomic identification of PT-containing microbes.

Temporal dynamics and metagenomics of phosphorothioate epigenomes in the human gut microbiome

The paper characterizes phosphorothioate (PT) modifications in the human gut microbiome using metagenomics and mass spectrometry, revealing temporal dynamics and species-specific patterns.

Mapping the tRNA Modification Landscape of Bartonella henselae Houston I and Bartonella quintana Toulouse

The paper maps tRNA modifications and their synthesis genes in two Bartonella species, identifying gene reductions linked to reductive evolution.

Alternate routes to mnm5s2U synthesis in Gram-positive bacteria

This paper identifies a novel pathway for mnm5s2U synthesis in Gram-positive bacteria, revealing alternative biosynthetic mechanisms involving the MnmL enzyme.

An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis

The paper identifies an RNA modification enzyme in Enterococcus faecalis that senses reactive oxygen species and regulates translation of stress-response proteins.

DNA Modifications Enabling Proximity Biotinylation

This paper introduces novel methods for proximity biotinylation of exogenous oligodeoxyribonucleotides using enzymatic tools and conjugation chemistries.

Queuine salvaging in the human parasite Entamoeba histolytica

This study identifies EhDUF2419 as the enzyme enabling Entamoeba histolytica to salvage queuine from gut bacteria, which is essential for tRNA modification and oxidative stress resistance.