Author

P. Dranchak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Organism:human· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

J. Inglese· 4 shared A. D. White· 1 shared A. Psaras· 1 shared B. Callahan· 1 shared B. L. Roth· 1 shared B. Queme· 1 shared C. L. Kohnhorst· 1 shared D. Blivis· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersPharmacology & Toxicology

J. Inglese

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity

R. T. Eastman, R. Rusinova, K. F. Herold, X.-P. Huang, P. Dranchak, T. C. Voss, S. Rana, J. H. Shrimp, A. D. White, H. C. Hemmings, B. L. Roth, J. Inglese, O. S. Andersen, J. L. Dahlin

This study shows ivermectin reduces SARS-CoV-2 viral burden in vitro but at concentrations that also cause cytotoxicity, suggesting its antiviral effect may be due to nonspecific membrane perturbation rather than specific antiviral activity.

bioRxiv · Oct 23, 2023 · PreprintPharmacology & Toxicology

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology

J. Inglese, P. Dranchak, E. Oliphant, B. Queme, L. Lamy, Y. Wang, R. Huang, M. Xia, D. Tao

This paper describes an in vivo qHTS method using C. elegans to assess drug toxicity and therapeutic potential, demonstrating its feasibility with anti-infective agents and toxicological compounds.

bioRxiv · Aug 26, 2022Pharmacology & Toxicology

Bioluminescence-based reporters for characterizing inhibitors and activators of human Sonic Hedgehog protein autoprocessing in live cells at high throughput.

D. Ciulla, P. Dranchak, J. Pezzullo, R. Mancusi, A. Psaras, G. Rai, J.-L. Giner, J. Inglese, B. Callahan

This paper develops a bioluminescence-based reporter system to monitor human SHhC autoprocessing in live cells for high-throughput screening of inhibitors and activators.

bioRxiv · Jun 27, 2022Biochemistry

High-content quantitative high-throughput screening identifies a cell cycle-associated signaling cascade that regulates a multienzyme metabolic assembly for glucose metabolism

D. L. Schmitt, P. Dranchak, P. Parajuli, D. Blivis, T. Voss, C. L. Kohnhorst, M. Kyoung, J. Inglese, S. An

This study identifies a cell cycle-associated signaling cascade regulating PFK1-mediated glucosome assembly through high-content screening and validation.

bioRxiv · Jun 10, 2022Biochemistry