Author

G. Rai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 7 Approach:experimental assay· 6 Assay:proteomics· 5 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Simeonov· 5 shared B. Baljinnyam· 4 shared A. V. Zakharov· 2 shared M. H. Ronzetti· 2 shared M. Shen· 2 shared S. Jain· 2 shared A. E. Owens· 1 shared A. Psaras· 1 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersBiochemistry

A. Simeonov

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Autoimmunity and clinical pathology amelioration in SLE by Dexamethasone primed Mesenchymal Stem Cell derived conditioned media

K. priya, S. Rawat, D. Das, M. Chaubey, H. Thacker, K. Giri, S. Singh, M. Rai, S. Mohanty, G. Rai

This study evaluates dexamethasone-primed mesenchymal stem cell conditioned media for treating SLE, showing improved immunomodulation and organ protection compared to standard therapies.

bioRxiv · Jun 29, 2024Immunology

Application of Temperature-Responsive HIS-Tag Fluorophores to Differential Scanning Fluorimetry Screening of Small Molecule Libraries

M. H. Ronzetti, B. Baljinnyam, Z. Itkin, S. Jain, G. Rai, A. V. Zakharov, U. Pal, A. Simeonov

The paper develops a high-throughput differential scanning fluorimetry assay using HIS-tag fluorophores to screen small molecule libraries for protein interactions.

bioRxiv · Aug 31, 2022Biochemistry

Bioluminescence-based reporters for characterizing inhibitors and activators of human Sonic Hedgehog protein autoprocessing in live cells at high throughput.

D. Ciulla, P. Dranchak, J. Pezzullo, R. Mancusi, A. Psaras, G. Rai, J.-L. Giner, J. Inglese, B. Callahan

This paper develops a bioluminescence-based reporter system to monitor human SHhC autoprocessing in live cells for high-throughput screening of inhibitors and activators.

bioRxiv · Jun 27, 2022Biochemistry

A comprehensive phenotypic screening strategy to identify modulators of cargo translocation by the bacterial Type IVB secretion system

E. Cheng, D. Dorjsuren, S. S. Lehman, C. L. Larson, S. Titus, H. Sun, A. Zakharov, G. Rai, R. A. Heinzen, A. Simeonov, M. P. Machner

This paper identifies compounds that inhibit T4SS-mediated effector delivery in pathogens, offering potential for pathogen-specific therapeutics.

mBio · Apr 26, 2022Peer-reviewedMicrobiology

A real-time cellular thermal shift assay (RT-CETSA) to monitor target engagement

T. W. Sanchez, M. H. Ronzetti, A. E. Owens, M. Antony, T. Voss, E. Wallgren, D. Talley, K. Balakrishnan, G. Rai, J. J. Marugan, S. Michael, B. Baljinnyam, N. Southall, A. Simeonov, M. J. Henderson

The paper introduces RT-CETSA, a real-time cellular thermal shift assay that improves throughput and sensitivity for monitoring ligand-target engagement in cells.

bioRxiv · Jan 24, 2022 · PreprintPharmacology & Toxicology

A hybrid in silico approach reveals novel inhibitors of multiple SARS-CoV-2 variants

S. Jain, D. C. Talley, B. Baljinnyam, J. Choe, Q. Hanson, W. Zhu, M. Xu, C. Z. Chen, W. Zheng, X. Hu, M. Shen, G. Rai, M. Hall, A. Simeonov, A. V. Zakharov

The paper uses a hybrid in silico approach combining machine learning and pharmacophore modeling on NCATS screening data to identify novel inhibitors effective against multiple SARS-CoV-2 variants.

bioRxiv · Jun 4, 2021Cell Biology

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

J. M. Rohde, K. R. Brimacombe, L. Liu, M. E. Pacold, A. Yasgar, D. M. Cheff, T. D. Lee, G. Rai, B. Baljinnyam, Z. Li, A. Simeonov, M. D. Hall, M. Shen, D. M. Sabatini, M. B. Boxer

The paper develops a biochemical assay to screen for PHGDH inhibitors, identifies piperazine-1-thiourea compounds, and evaluates their biological impact on serine metabolism in cancer cells.

bioRxiv · Jan 19, 2018Cancer Biology