J. Inglese

Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity

This study shows ivermectin reduces SARS-CoV-2 viral burden in vitro but at concentrations that also cause cytotoxicity, suggesting its antiviral effect may be due to nonspecific membrane perturbation rather than specific antiviral activity.

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology

This paper describes an in vivo qHTS method using C. elegans to assess drug toxicity and therapeutic potential, demonstrating its feasibility with anti-infective agents and toxicological compounds.

Bioluminescence-based reporters for characterizing inhibitors and activators of human Sonic Hedgehog protein autoprocessing in live cells at high throughput.

This paper develops a bioluminescence-based reporter system to monitor human SHhC autoprocessing in live cells for high-throughput screening of inhibitors and activators.

High-content quantitative high-throughput screening identifies a cell cycle-associated signaling cascade that regulates a multienzyme metabolic assembly for glucose metabolism

This study identifies a cell cycle-associated signaling cascade regulating PFK1-mediated glucosome assembly through high-content screening and validation.

Comparison of Janus kinase inhibitors to block the type I interferon pathway in human skeletal muscle cells

This study compares the effectiveness of 48 JAK inhibitors in blocking the JAK1/TYK2-dependent type I interferon-MHC class I pathway in human skeletal muscle cells.

High throughput screening to identify inhibitors of the type I interferon - major histocompatibility complex class I pathway in skeletal muscle

A Homogeneous SIRPα-CD47 Cell-Based, Ligand-Binding Assay: Utility for Small Molecule Drug Development in Immuno-oncology.

This paper develops a cell-based ligand-binding assay to identify small molecule inhibitors of the SIRP-CD47 interaction for immuno-oncology drug development.