P. Kursula

The cytoplasmic tail of myelin protein zero induces morphological changes in lipid membranes

This paper investigates how the cytoplasmic tail of P0 affects lipid membrane morphology and describes the production of full-length P0 for further study.

Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc

This paper characterizes two anti-Arc nanobodies that bind to the ligand-binding pocket of human Arc-NL, revealing their structural and functional properties as competitive inhibitors.

Structural properties of the HNF-1A transactivation domain

The paper characterizes the disordered structure and functional properties of the HNF-1A transactivation domain using bioinformatics and biophysical methods.

Conformational analysis of membrane-proximal segments of GDAP1 in a lipidic environment using synchrotron radiation suggests a mode of assembly at the mitochondrial outer membrane

This study uses synchrotron radiation and spectroscopy to model GDAP1 assembly at the mitochondrial outer membrane, suggesting a single transmembrane helix flanked by peripheral helices.

The intrinsically disordered protein glue of myelin: Linking AlphaFold2 predictions to experimental data

This study links AlphaFold2 predictions of myelin-specific intrinsically disordered proteins to experimental data, showing helical segments in predicted models match membrane-binding sites.

Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability

This study analyzes GDAP1 mutations linked to CMT, showing they affect protein stability and conserved intramolecular networks, potentially leading to mitochondrial dysfunction and neuronal degeneration.

Structural characterization of functionally important chloride binding sites in the marine Vibrio alkaline phosphatase

This study identifies two chloride binding sites in Vibrio alkaline phosphatase using X-ray crystallography and SAXS, showing chloride enhances catalytic efficiency and stability through structural modulation.

Human myelin proteolipid protein structure and lipid bilayer stacking

This study determines the structure of human myelin proteolipid protein (PLP) and its isoform DM20, revealing their dimeric conformation and role in membrane stacking and organization.

Structural insights into Charcot-Marie-Tooth disease-linked mutations in human GDAP1

This study investigates the structural and biochemical effects of CMT-linked GDAP1 mutations, finding reduced thermal stability and disrupted interaction networks that may impair neuronal function.

Structural and biophysical characterization of HNF-1A as a tool to study MODY3 diabetes variants

This study structurally and biophysically characterizes HNF-1A variants associated with MODY3 diabetes, showing reduced functionality in three variants compared to wild-type.

High-affinity nanobodies as tools for structural and functional studies on mammalian Arc

This study produces and characterizes high-affinity anti-Arc nanobodies, revealing structural dynamics of Arc CTD and its role in oligomerization and capsid formation.

Human myelin protein P2: From crystallography to time-lapse membrane imaging and neuropathy-associated variants

This study investigates the structural and functional properties of P2 variants associated with Charcot-Marie-Tooth disease using crystallography, spectroscopy, and imaging techniques.

Structural properties and peptide ligand binding of the capsid homology domains of human Arc

This study identifies conserved interactions in the Arc protein's peptide binding site and characterizes its structural properties and potential functional roles in synaptic processes.

Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc

This study compares the structural properties of dArc lobes to mammalian Arc, showing dArc forms oligomers while mammalian Arc is monomeric, suggesting different capsid assembly mechanisms.

Structure of the complete dimeric human GDAP1 core domain provides insights into ligand binding and clustering of disease mutations

The paper determines the crystal structure of the human GDAP1 core domain, identifies a fatty acid ligand, and reveals structural insights into disease-related mutations and oligomerization.

Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase

The paper determines the crystal structure of mouse CSAD, identifies substrate specificity determinants, and shows open/close motions in solution.

Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment

This study determines the crystal structure of the AnxA11 core, identifies a stabilizing N-terminal segment, and links three ALS mutations to conserved arginine residues critical for annexin folding.

Determinants for forming a supramolecular myelin-like proteolipid lattice

This study uses structural and functional analyses to reveal how myelin protein P2 forms a supramolecular lattice between lipid bilayers, identifying key residues and interactions involved in membrane binding.

Molecular determinants of Arc oligomerization and formation of virus-like capsids

This paper identifies a 28-amino-acid region in Arc critical for oligomerization and virus-like capsid formation, showing that exogenous RNA enhances assembly.

Sub-atomic resolution crystal structures reveal conserved geometric outliers at functional sites

The paper presents high-resolution crystal structures of P2, revealing non-ideal conformations and geometric outliers that may be functionally significant.

Neuropathy-related mutations alter the membrane binding properties of the human myelin protein P0 cytoplasmic tail

This study investigates how neuropathy-related mutations in the cytoplasmic tail of the human myelin protein P0 affect its membrane binding properties and function.

Ionic strength and calcium regulate the membrane interactions of myelin basic protein and the cytoplasmic domain of myelin protein zero

This study investigates how ionic strength and calcium influence the membrane interactions of myelin basic protein and the cytoplasmic domain of P0, showing their impact on lipid vesicle aggregation.

Molecular structure and function of myelin protein P0 in membrane stacking

This study characterizes the molecular structure and function of myelin protein P0, showing how its extracellular domains stack lipid membranes and stabilize the intraperiod line in peripheral myelin.

Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities

This study determines the structure of monomeric full-length ARC, revealing its compact conformation and interaction sites for postsynaptic proteins and phospholipid membranes.