The Arp2/3 complex promotes periodic removal of Pak1-mediated negative feedback to facilitate anticorrelated Cdc42 oscillations.
M. Harrell, Z. Liu, B. F. Campbell, O. Chinsen, T. Hong, M. E. Das
This study shows that the Arp2/3 complex enables Pak1 removal through endocytosis, allowing Cdc42 reactivation and oscillations in S. pombe.
bioRxiv · Nov 8, 2023Cell Biology