P. Munoz-Tello

This study identifies a conserved Trp-Pro motif in PPARγ AF-1 that undergoes cis/trans isomerization, enabling interdomain communication with the LBD and affecting transcriptional activity.

The paper assesses twelve NR4A ligands to determine if they directly bind and modulate Nurr1 or act through effector proteins, finding some bind directly while others do not.

The paper shows synthetic and natural ligands can bind cooperatively to PPARγ, altering its structure and function through a 'ligand link' to the omega loop.

This study shows the Nurr1 ligand-binding domain has a dynamic, solvent-accessible pocket that can bind unsaturated fatty acids, challenging the notion that it lacks a canonical ligand-binding pocket.