ImmunologybioRxiv
Human IL-2 receptor β mutations associated with defects in immunity and peripheral tolerance
Z. Zhang, F. Gothe, P. Pennamen…·M. J. Lenardo
This study identifies IL-2Rβ gene mutations causing immune and tolerance defects, showing variable expression impacts on T and NK cells and informing IL-2-based therapies.
DOI 10.1084/jem.20182304