Author

F. Gothe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

S. Hambleton· 3 shared C. F. Hatton· 2 shared C. J. A. Duncan· 2 shared A. Alazami· 1 shared A. C. M. Khan· 1 shared A. I. Gardner· 1 shared A. T. Hanrath· 1 shared B. J. Thompson· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

S. Hambleton

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Type I interferons govern Zika virus resistance of human macrophages and microglia

A. T. Hanrath, C. F. Hatton, F. Gothe, C. Browne, J. Vowles, P. Leary, S. J. Cockell, S. A. Cowley, W. S. James, S. Hambleton, C. J. A. Duncan

This study shows that type I interferons restrict Zika virus replication in macrophages and microglia, and their suppression increases viral replication and cell damage.

bioRxiv · Mar 9, 2022 · PreprintCell Biology

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

C. F. Hatton, R. A. Botting, M. E. Duenas, I. J. Haq, B. Verdon, B. J. Thompson, J. Stremenova Spegarova, F. Gothe, E. A. Stephenson, A. I. Gardner, S. Murphy, J. Scott, J. P. Garnett, S. Carrie, J. Powell, , C. J. A. Duncan

This study shows that delayed type I and III interferon responses in nasal epithelial cells allow SARS-CoV-2 replication, but pre-infection IFN treatment restricts virus and preserves barrier integrity.

bioRxiv · Feb 17, 2021Immunology

Human IL-2 receptor β mutations associated with defects in immunity and peripheral tolerance

Z. Zhang, F. Gothe, P. Pennamen, J. James, D. MacDonald, C. P. Mata, Y. Modis, M. Acres, W. Haller, C. Bowen, R. Doffinger, J. Sinclair, S. Brothers, A. Alazami, Y. Zhang, , M. J. Lenardo

This study identifies IL-2Rβ gene mutations causing immune and tolerance defects, showing variable expression impacts on T and NK cells and informing IL-2-based therapies.

bioRxiv · Nov 26, 2018Immunology