Human IL-2 receptor β mutations associated with defects in immunity and peripheral tolerance
Z. Zhang, F. Gothe, P. Pennamen, J. James, D. MacDonald, C. P. Mata, Y. Modis, M. Acres, W. Haller, C. Bowen, R. Doffinger, J. Sinclair, S. Brothers, A. Alazami, Y. Zhang, , M. J. Lenardo
This study identifies IL-2Rβ gene mutations causing immune and tolerance defects, showing variable expression impacts on T and NK cells and informing IL-2-based therapies.
bioRxiv · Nov 26, 2018Immunology