P. aeruginosa tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis
Z. Li, R. Barnaby, A. Nymon, C. Roche, K. Koeppen, A. Ashare, D. Hogan, S. A. Gerber, D. Taatjes, T. H. Hampton, B. Stanton
This paper shows tobramycin reduces inflammation in cystic fibrosis by increasing 5' tRNA-fMet halves in P. aeruginosa outer membrane vesicles, which suppress IL-8 and neutrophilic inflammation in human cells and mice.
bioRxiv · Feb 3, 2024 · PreprintMicrobiology