Author

P. Tschaikner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

E. Stefan· 3 shared D. Regele· 2 shared A. Feichtner· 1 shared A. Manglik· 1 shared A. S. Evers· 1 shared C.-M. Suomivuori· 1 shared D. F. Covey· 1 shared D. S. Marks· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

E. Stefan

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Author profile →

3 papers

Recent·Most cited

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway

N. Hoppe, S. Harrison, S.-H. Hwang, Z. Chen, M. Karelina, I. Deshpande, C.-M. Suomivuori, V. R. Palicharla, S. P. Berry, P. Tschaikner, D. Regele, D. F. Covey, E. Stefan, D. S. Marks, J. Reiter, , A. Manglik

The paper determines the cryo-EM structure of active GPR161 bound to Gs, revealing sterol binding and its role in ciliary cAMP signaling, while showing that sterol binding is not essential for Hedgehog pathway suppression.

Nature Structural & Molecular Biology · Feb 7, 2024Peer-reviewedBiochemistry

Kinases in motion: impact of protein and small molecule interactions on kinase conformations

V. Kugler, S. Schwaighofer, A. Feichtner, F. Enzler, J. Fleischmann, S. Strich, S. Schwarz, R. Wilson, P. Tschaikner, J. Troppmair, V. Sexl, P. Meier, T. Kaserer, E. Stefan

This study uses KinCon-reporter technology to analyze conformational changes in disease-associated kinases upon drug, regulatory protein, and pathway activation interactions, revealing insights into therapeutic strategies.

bioRxiv · Jan 11, 2024Biochemistry

Zebrafish Gpr161 contributes to basal hedgehog repression in a tissue-specific manner

P. Tschaikner, D. Regele, W. Salvenmoser, S. Geley, E. Stefan, P. Aanstad

This study shows that Gpr161 contributes to tissue-specific basal repression of Hedgehog signaling in zebrafish by modulating PKA activity in the neural tube and myotome.

bioRxiv · Apr 23, 2019 · PreprintCell Biology