Hepatic lipid overload potentiates biliary epithelial cell activation via E2Fs
E. Yildiz, G. El Alam, A. Perino, A. Jalil, P.-D. Denechaud, K. Huber, L. Fajas, J. Auwerx, G. Sorrentino, K. Schoonjans
This study shows lipid overload activates E2F transcription factors in biliary epithelial cells, driving cell cycle progression and glycolytic metabolism to initiate ductular reaction without epithelial damage.
eLife · Mar 6, 2023Peer-reviewedCell Biology