Author

A. Jalil

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Perino· 2 shared K. Schoonjans· 2 shared A. Alonso-Calleja· 1 shared A. Geissler· 1 shared A. Hamai· 1 shared A. Laubriet· 1 shared A. Martins· 1 shared Alex Kasznel· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCell Biology

A. Perino

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The bile acid receptor TGR5 is a modulator of bone marrow adipose tissue and the hematopoietic niche

A. Alonso-Calleja, A. Perino, F. Schyrr, S. Ferreira Lopes, V. Delitsikou, A. Jalil, U. Kettenberger, M. C. Galavotti, A. Martins, C. Bataclan, D. P. Pioletti, K. Schoonjans, O. Naveiras

This study shows TGR5 modulates bone marrow adipose tissue and hematopoietic niche in a sex-dependent manner, affecting progenitor reconstitution and myeloid recovery.

bioRxiv · Nov 22, 2023 · PreprintCell Biology

Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis

C. Thomas, K. Van Dongen, D. Leleu, T. Pilot, A. Jalil, L. Mangin, L. Menegaut, A. Geissler, S. IVANOV, A. Laubriet, V. Crespy, M. Nguyen, e. steinmetz, D. Masson, T. Gautier

This study shows that atheroma plaque microenvironment activates the kynurenine pathway in macrophages, increasing kynurenine production which induces endothelial adhesion molecules, promoting atherogenesis.

bioRxiv · Jul 19, 2023 · PreprintImmunology

Hepatic lipid overload potentiates biliary epithelial cell activation via E2Fs

E. Yildiz, G. El Alam, A. Perino, A. Jalil, P.-D. Denechaud, K. Huber, L. Fajas, J. Auwerx, G. Sorrentino, K. Schoonjans

This study shows lipid overload activates E2F transcription factors in biliary epithelial cells, driving cell cycle progression and glycolytic metabolism to initiate ductular reaction without epithelial damage.

eLife · Mar 6, 2023Peer-reviewedCell Biology

The HP1γ epigenetic silencer dampens IFN-γ response at the gut epithelial barrier

Y. Chang, J. Mata-Garrido, C. desterke, E. Batsche, A. Hamai, S. Youssouf, D. Skurnik, A. Jalil, J.-C. Beche, E. Piaggio, L. Arbibe, Y. C. Marchand

This study identifies HP1γ as an epigenetic repressor of IFN-γ responsive genes at the gut epithelial barrier, showing its role in dampening immune responses.

bioRxiv · Dec 27, 2022 · PreprintImmunology

Heterogeneous strains in tissue collagen show that high strains locally suppress degradation by collagenase

Karanvir Saini, M. Tiwari, Sangkyun Cho, A. Jalil, Manasvita Vashisth, Jerome Irianto, Jason C. Andrechak, Lawrence J. Dooling, Cory M. Alvey, Alex Kasznel, David M. Chenoweth, K. Yamamoto, Dennis E. Discher

This paper investigates how mechanical strain affects collagen degradation in tendon and heart tissues, finding that moderate strains suppress degradation while higher strains do not.

bioRxiv · Feb 7, 2021 · PreprintMolecular Biology