Author

L. Fajas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

K. Huber· 2 shared P.-D. Denechaud· 2 shared A. Bonnefond· 1 shared A. Jalil· 1 shared A. Perino· 1 shared C. Bourouh· 1 shared C. Carney· 1 shared C. Roger· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

K. Huber

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Author profile →

3 papers

Recent·Most cited

Hepatic lipid overload potentiates biliary epithelial cell activation via E2Fs

E. Yildiz, G. El Alam, A. Perino, A. Jalil, P.-D. Denechaud, K. Huber, L. Fajas, J. Auwerx, G. Sorrentino, K. Schoonjans

This study shows lipid overload activates E2F transcription factors in biliary epithelial cells, driving cell cycle progression and glycolytic metabolism to initiate ductular reaction without epithelial damage.

eLife · Mar 6, 2023Peer-reviewedCell Biology

CDK4 deletion in mice prevents fat accumulation and increases endurance capacity through activation of estrogen related receptor (ERR)driven oxidative metabolism in skeletal muscle

V. Barquissau, N. Zanou, S. Geller, J. Castillo-Armengol, F. Marzetta, k. Huber, D. Ziegler, I. Lopez-Mejia, J. Blanco Fernandez, C. Roger, N. Guex, F. Preitner, J. M. Vanacker, L. Fajas

This study shows that CDK4 deletion in mice improves endurance and reduces fat accumulation by enhancing ERR-driven oxidative metabolism in skeletal muscle.

bioRxiv · Mar 3, 2022 · PreprintPhysiology

Pancreatic β-cell specific loss of E2f1 impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programs

F. Oger, C. Bourouh, X. Gromada, M. Moreno, C. Carney, E. Courty, N. Rabhi, E. Durand, S. Amanzougarene, L. Berberian, M. Derhourhi, L. Rolland, S. A. Hannou, P.-D. Denechaud, Z. Benfodda, , J.-S. ANNICOTTE

bioRxiv · Oct 14, 2020Physiology