Author

K. Schoonjans

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:development & morphogenesis· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:organoid / primary culture· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Jalil· 2 shared A. Perino· 2 shared E. Yildiz· 2 shared G. Sorrentino· 2 shared J. Auwerx· 2 shared A. Alonso-Calleja· 1 shared A. Martins· 1 shared B. E. Kang· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

A. Jalil

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The bile acid receptor TGR5 is a modulator of bone marrow adipose tissue and the hematopoietic niche

A. Alonso-Calleja, A. Perino, F. Schyrr, S. Ferreira Lopes, V. Delitsikou, A. Jalil, U. Kettenberger, M. C. Galavotti, A. Martins, C. Bataclan, D. P. Pioletti, K. Schoonjans, O. Naveiras

This study shows TGR5 modulates bone marrow adipose tissue and hematopoietic niche in a sex-dependent manner, affecting progenitor reconstitution and myeloid recovery.

bioRxiv · Nov 22, 2023 · PreprintCell Biology

Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

Y. Kim, K.-Y. Jung, Y. H. Kim, P. Xu, Y. Jo, B. E. Kang, N. Pandit, J. Kwon, K. Gariani, J. Gariani, J. Lee, J. Verbeek, S. Nam, S.-J. Bae, K.-T. Ha, , J. Auwerx

This study shows that SIRT7 contributes to sorafenib resistance in HCC by enhancing ERK phosphorylation, and inhibiting SIRT7 with sorafenib reduces tumor growth.

bioRxiv · Mar 13, 2023 · PreprintCancer Biology

Hepatic lipid overload potentiates biliary epithelial cell activation via E2Fs

E. Yildiz, G. El Alam, A. Perino, A. Jalil, P.-D. Denechaud, K. Huber, L. Fajas, J. Auwerx, G. Sorrentino, K. Schoonjans

This study shows lipid overload activates E2F transcription factors in biliary epithelial cells, driving cell cycle progression and glycolytic metabolism to initiate ductular reaction without epithelial damage.

eLife · Mar 6, 2023Peer-reviewedCell Biology

Mechano-modulatory synthetic niches for liver organoid derivation

G. Sorrentino, S. Rezakhani, E. Yildiz, S. Nuciforo, M. Heim, M. Lutolf, K. Schoonjans

This study develops chemically defined hydrogels to derive mouse and human liver organoids, showing stiffness sensitivity and YAP/SFK dependence, and establishes biopsy-derived human liver organoids without animal components.

bioRxiv · Oct 18, 2019Bioengineering