F. Ginhoux

Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice

This study shows that monocyte-derived microglia with a Dnmt3a mutation cause motor deficits in aging mice, resembling Parkinsonian disorders.

Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration

This study identifies circulating senescent myeloid cells as drivers of blood-brain barrier breakdown and neurodegeneration in LCH-ND.

Immunomodulatory Leptin Receptor+ Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis

This paper identifies leptin receptor-expressing sympathetic perineurial cells that produce IL33, which prevents BAT inflammation and obesity by supporting thermogenesis and immune regulation.

Cell-type specific innate immune responses shape rabies virus tropism

This study investigates how cell-type specific innate immune responses influence rabies virus tropism by comparing susceptibility and antiviral responses in different CNS cell types.

Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation

This study identifies Apolipoprotein E's role in Dectin-1-dependent development of monocyte-derived alveolar macrophages during pulmonary β-glucan-induced inflammation.

A Shape Sensing Mechanism driven by Arp2/3 and cPLA2 licenses Dendritic Cells for Migration to Lymph Nodes in Homeostasis

The paper identifies a shape sensing mechanism in dendritic cells that links cell motility to CCR7 expression, enabling migration to lymph nodes through ARP2/3-cPLA2 signaling.

CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration following radiation-induced injury

This study identifies CSF1R-dependent macrophages as critical for epithelial regeneration after radiation-induced salivary gland injury.

Single-cell RNA-Seq analysis reveals dual sensing of HIV-1 in blood Axl+ dendritic cells

This study identifies two distinct transcriptional responses in Axl+ dendritic cells to HIV-1, mediated by NF-κB and STAT1/2 pathways, with implications for viral transmission and immune activation.

Tissue-resident FOLR2+ macrophages associate with tumor-infiltrating CD8+ T cells and with increased survival of breast cancer patients.

The paper identifies FOLR2+ macrophages in breast cancer that correlate with improved patient survival and co-localize with CD8+ T cells across multiple cancers.

Next generation vaccine platform: polymersomes as stable nanocarriers for a highly immunogenic and durable SARS-CoV-2 spike protein subunit vaccine

This paper develops a subunit vaccine using polymersomes to deliver SARS-CoV-2 spike protein and CpG adjuvant, showing robust and durable immune responses in mice.

Proliferative and quiescent human gastric cancer stem-like cells are associated with differential chemoresistance and patient mortality

This study identifies two stem-like gastric cancer subpopulations with distinct chemoresistance and survival outcomes using scRNA-seq and organoid models.

Phenotypic and functional characterisation of first trimester human placental macrophages, Hofbauer cells.

The paper characterizes first trimester human placental macrophages, identifying Hofbauer cells as HLA-DR-FOLR2+ macrophages with microbicidal properties and secreted factors influencing placental angiogenesis.

Open Source ImmGen: network perspective on metabolic diversity among mononuclear phagocytes

The paper analyzes metabolic diversity in mononuclear phagocytes across tissues using integrated datasets and a network-based approach, identifying key metabolic subnetworks and their functional roles.

Infinity Flow: High-throughput single-cell quantification of 100s of proteins using conventional flow cytometry and machine learning

Infinity Flow uses flow cytometry and machine learning to analyze hundreds of proteins across millions of cells, revealing novel lung cellular heterogeneity in melanoma metastasis models.

Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Endosomal Sensing by Dendritic Cells in Psoriasis

This study shows that excessive polyamine production in keratinocytes drives self-RNA sensing by dendritic cells, contributing to psoriasis inflammation.

Engineered niches support the development of human dendritic cells in humanized mice

This study shows engineered mesenchymal stromal cells can generate human dendritic cells in vivo, closely resembling blood-derived cDCs.

Trimester-specific Zika virus infection affects placental responses in women

This study examines how ZIKV infection during different pregnancy trimesters affects placental immune and transcriptomic responses, identifying unique molecular changes associated with early infection.

A rule-based data-informed cellular consensus map of the human mononuclear phagocyte cell space

The paper develops a rule-based data-informed approach to create a consensus map of the human mononuclear phagocyte cell space using computational integration and single-cell RNA-sequencing.

Fate mapping via Ms4a3 expression history traces monocyte-derived cells

The paper identifies Ms4a3 as a marker for tracking monocyte-derived cells and quantifies their contribution to tissue-resident macrophages during homeostasis and inflammation.

Constitutive Siglec-1 expression by human dendritic cell precursors enables HIV-1 replication and transmission

This study identifies pre-DC as a unique blood DC subset that supports HIV-1 replication and transmission through Siglec-1 expression.

Enterococcus faecalis Promotes Innate Immune Suppression And Polymicrobial Catheter-Associated Urinary Tract Infection

This study shows E. faecalis suppresses macrophage NF-κB signaling and promotes polymicrobial CAUTI by enhancing E. coli infection.

Enterococcus faecalis Modulates Immune Activation And Slows Healing During Wound Infection

This study shows that high-dose Enterococcus faecalis infections in mice lead to immune modulation, bacterial persistence, and delayed wound healing.