Franz Oswald

The paper shows that ribosomal error-rate adapts in human aging models but not in mouse models, involving ER-stress signaling and Alzheimer's proteins.

The paper investigates RBPJ-DNA binding kinetics and cofactor interactions, finding that kinetic stability, not thermodynamic, governs target site specificity and that mutations affect both association and dissociation rates.

This study uses a Drosophila Su(H) model to show that AOS-linked RBPJ variants cause developmental defects by sequestering Notch cofactors, leading to dysregulated target gene expression.