Cell BiologybioRxivPreprint
Lactylation-driven FTO-mediated m6A modification of CDK2 aggravates diabetic microvascular anomalies
X. Chen, R.-X. Sun, J.-N. Wang…·Q.-H. Liu
This study shows that FTO, through lactylation-driven m6A modification of CDK2, worsens diabetic retinopathy by promoting angiogenesis and inflammation, and presents a nanotherapeutic approach to inhibit FTO.