Author

R. Beckwith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Fazal· 2 shared J. Solomon· 2 shared W. Shu· 2 shared A. A. Golosov· 1 shared A. Burke· 1 shared A. Frommlet· 1 shared A. Godbole· 1 shared A. Hachey· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

A. Fazal

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2 papers

Recent·Most cited

A small molecule VHL molecular glue degrader for cysteine dioxygenase 1

A. Tutter, D. Buckley, A. A. Golosov, X. Ma, W. Shu, D. J. Mckay, V. Darsigny, D. Dovala, R. Beckwith, J. Solomon, P. Rao, L. Xu, A. Fazal, A. Lingel, C. Wartchow, , G. A. Michaud

The paper identifies a small molecule that acts as a molecular glue degrader for CDO1 by recruiting it into the VHL E3 ligase complex, leading to its degradation.

Nature Chemical Biology · Jun 24, 2025Peer-reviewedBiochemistry

The Structural Basis of Indisulam-Mediated Recruitment of RBM39 to the DCAF15-DDB1-DDA1 E3 Ligase Complex

D. E. Bussiere, L. Xie, W. Shu, H. Srinivas, W. Shu, A. Burke, C. Be, J. Zhao, A. Godbole, D. King, R. G. Karki, V. Hornak, F. Xu, J. Cobb, N. Carte, , J. Paulk

This study determines the structure of the DCAF15-DDB1-DDA1-Indisulam-RBM39 complex, revealing how Indisulam promotes RBM39 degradation via a novel degron motif.

bioRxiv · Aug 16, 2019Biophysics