Author

A. Fazal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

J. Solomon· 2 shared R. Beckwith· 2 shared R. F. Seipke· 2 shared W. Shu· 2 shared A. A. Golosov· 1 shared A. Burke· 1 shared A. Frommlet· 1 shared A. Godbole· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

J. Solomon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A small molecule VHL molecular glue degrader for cysteine dioxygenase 1

A. Tutter, D. Buckley, A. A. Golosov, X. Ma, W. Shu, D. J. Mckay, V. Darsigny, D. Dovala, R. Beckwith, J. Solomon, P. Rao, L. Xu, A. Fazal, A. Lingel, C. Wartchow, , G. A. Michaud

The paper identifies a small molecule that acts as a molecular glue degrader for CDO1 by recruiting it into the VHL E3 ligase complex, leading to its degradation.

Nature Chemical Biology · Jun 24, 2025Peer-reviewedBiochemistry

Regulation of antimycin biosynthesis is controlled by the ClpXP protease

B. Bilyk, S. Kim, A. Fazal, T. A. Baker, R. F. Seipke

This paper shows that the ClpXP protease regulates the abundance of σAntA, an ECF σ factor controlling antimycin biosynthesis in Streptomyces.

mSphere · Apr 29, 2020Peer-reviewedMicrobiology

The Structural Basis of Indisulam-Mediated Recruitment of RBM39 to the DCAF15-DDB1-DDA1 E3 Ligase Complex

D. E. Bussiere, L. Xie, W. Shu, H. Srinivas, W. Shu, A. Burke, C. Be, J. Zhao, A. Godbole, D. King, R. G. Karki, V. Hornak, F. Xu, J. Cobb, N. Carte, , J. Paulk

This study determines the structure of the DCAF15-DDB1-DDA1-Indisulam-RBM39 complex, revealing how Indisulam promotes RBM39 degradation via a novel degron motif.

bioRxiv · Aug 16, 2019Biophysics

A chromatogram-simplified Streptomyces albus host for heterologous production of natural products

A. Fazal, D. Thankachan, E. Harris, R. F. Seipke

This study creates a simplified Streptomyces albus host that can express foreign biosynthetic gene clusters to produce natural products.

bioRxiv · Apr 18, 2019Microbiology