Author

J. Cobb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Biophysics· 1 Evolutionary Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Burke· 1 shared A. E. Loiselle· 1 shared A. F. Azad· 1 shared A. Fazal· 1 shared A. Frommlet· 1 shared A. Godbole· 1 shared A. Ibrahim· 1 shared A. Mojumdar· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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1 shared paperBiophysics

A. Burke

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Efficacy of an oral lipid nanocrystal (LNC) formulation of amphotericin B (MAT2203) in the neutropenic mouse model of pulmonary mucormycosis

Y. Gu, T. Gebremariam, S. Alkhazraji, E. Youssef, S. El-Gamal, T. Matkovits, J. Cobb, R. Mannino, A. Ibrahim

This study compares the efficacy of oral MAT2203 to intravenous LAMB in a neutropenic mouse model of mucormycosis, finding MAT2203 as effective in survival and fungal burden reduction.

bioRxiv · Nov 22, 2023Microbiology

Loss of Dna2 nuclease activity results in decreased Exo1-mediated resection at DNA double strand breaks.

A. Mojumdar, C. Granger, M. Lunke, J. Cobb

This study shows that loss of Dna2 nuclease activity reduces Exo1-mediated resection at DNA double strand breaks, leading to increased NHEJ and decreased HR.

bioRxiv · Oct 25, 2023 · PreprintBiochemistry

Pathogenic, but not non-pathogenic, Rickettsia evade inflammasome-dependent IL-1 responses to establish an intracytosolic replication niche.

O. H. Voss, J. Cobb, H. Gaytan, N. Rivera Diaz, R. Sanchez, L. DeTolla, M. S. Rahman, A. F. Azad

This study shows pathogenic Rickettsia species evade IL-1 responses via Caspase-11-Gsdmd pathway to replicate intracellularly, unlike non-pathogenic Rickettsia.

bioRxiv · Sep 8, 2021 · PreprintMicrobiology

Development of a Murine Model of Pyogenic Flexor Tenosynovitis

B. Qiu, J. Cobb, A. E. Loiselle, C. Ketonis

This paper develops a murine model of pyogenic flexor tenosynovitis using Staphylococcus aureus infection and evaluates its progression through bioluminescence and histopathology.

bioRxiv · Feb 7, 2020Pathology

The Structural Basis of Indisulam-Mediated Recruitment of RBM39 to the DCAF15-DDB1-DDA1 E3 Ligase Complex

D. E. Bussiere, L. Xie, W. Shu, H. Srinivas, W. Shu, A. Burke, C. Be, J. Zhao, A. Godbole, D. King, R. G. Karki, V. Hornak, F. Xu, J. Cobb, N. Carte, , J. Paulk

This study determines the structure of the DCAF15-DDB1-DDA1-Indisulam-RBM39 complex, revealing how Indisulam promotes RBM39 degradation via a novel degron motif.

bioRxiv · Aug 16, 2019Biophysics

An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice

J. L. P. Castro, M. N. Yancoskie, M. Marchini, S. Belohlavy, M. Kucka, W. H. Beluch, R. Naumann, I. Skuplik, J. Cobb, N. H. Barton, C. Rolian, Y. F. Chan

This study analyzes the genomic changes in mice selectively bred for longer limbs, identifying polygenic adaptation and major-effect loci linked to bone growth regulation.

bioRxiv · Aug 19, 2018Evolutionary Biology