P. Rao

A small molecule VHL molecular glue degrader for cysteine dioxygenase 1

The paper identifies a small molecule that acts as a molecular glue degrader for CDO1 by recruiting it into the VHL E3 ligase complex, leading to its degradation.

Bond strength between receptor binding domain of spike protein and human angiotensin converting enzyme-2 using machine learning.

This study predicts bond strength between SARS-CoV-2 spike protein RBD and ACE2 using machine learning, achieving high accuracy matching ab initio calculations for wild-type and Omicron variants.

Myosin VIII and XI isoforms interact with Agrobacterium VirE2 protein and help direct transport from the plasma membrane to the perinuclear region during plant transformation

The paper identifies myosin VIII isoforms as facilitators of VirE2 plasma membrane tethering and myosin XI-K as essential for VirE2 cytoplasmic transport during Agrobacterium-mediated plant transformation.

Genomic perspectives of SARS CoV-2 in liver disease patients with its clinical correlation: A single centre retrospective study

This study compares the mutational and clinical profiles of liver disease patients infected with different SARS CoV-2 variants, finding higher mortality risk and specific genetic mutations associated with adverse outcomes.

Purification and biochemical analysis of native AMPA receptors from three different mammalian species

This study isolates and analyzes native AMPA receptors from pig, sheep, and cow brains, showing structural and biochemical analysis is feasible in ungulates, which are evolutionarily closer to humans than rodents.

A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

The paper develops a 15-gene immune signature to identify T-cell infiltration in high-risk paediatric cancers, finding up to 31% of such cancers have infiltrating T-cells.

Fish oil Nano-emulsion Kills Macrophage: Ferroptosis and Autophagy Triggered by Catalase-catalysed Superoxide Eruption

The paper shows fish oil nano-emulsions trigger ferroptosis and autophagy in macrophages via catalase-catalyzed superoxide production, leading to oxidative damage.

RelCoVax(R), a two antigen subunit protein vaccine candidate against SARS-CoV-2 induces strong immune responses in mice

RelCoVax(R), a dual RBD and N subunit vaccine, induces strong antibody and Th1 cellular responses and neutralizes SARS-CoV-2 strains in mice.

Delta variant with P681R critical mutation revealed by ultra-large atomic-scale ab initio simulation: Implications for the fundamentals of biomolecular interactions

The paper uses ab initio simulations to analyze the P681R and D614G mutations in the SARS-CoV-2 spike protein, showing they reduce atomic bonding cohesion and increase flexibility, potentially aiding in predicting future mutations.

Evaluation of Safety and Immunogenicity of an Adjuvanted, TH-1 Skewed, Whole Virion Inactivated SARS-CoV-2 Vaccine - BBV152

This study evaluates the safety and immunogenicity of a SARS-CoV-2 vaccine BBV152 in mice, rats, and rabbits, showing high antibody titers and Th1-biased responses with the TLR7/8 agonist adjuvant.

JUUL and Combusted Cigarettes Comparably Impair Endothelial Function

This study shows that JUUL and previous generation e-cig aerosol impair endothelial function in rats similarly to cigarette smoke.