R. Botelho

Arf1-PI4KIIIβ positive vesicles regulate phosphatidylinositol-3-phosphate signalling to facilitate the fission of lysosomal tubules.

This study identifies Arf1-PI4KIIIβ positive vesicles as regulators of PI(3)P signaling essential for lysosomal tubule fission across different lysosomal organelles.

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation

This study identifies mTORC1-dependent translation as a mechanism for endo-lysosome expansion and antigen presentation during phagocyte activation.

Phosphatidylinositol Cycle Disruption is Central to Atypical Hemolytic-Uremic Syndrome Caused by Diacylglycerol Kinase Epsilon Deficiency

This study investigates DGKE deficiency in aHUS using lipidomic analysis and finds reduced PtdIns(4,5)P2, not increased DAG, is critical to the disease's pro-thrombotic phenotype.