LRRC8A regulates hypotonicity-induced NLRP3 inflammasome activation
J. P. Green, T. Swanton, L. V. Morris, L. Y. El-Sharkawy, J. Cook, S. Yu, J. Beswick, A. D. Adamson, N. E. Humphreys, R. Bryce, S. Freeman, C. Lawrence, D. Brough
This study identifies LRRC8A as a key regulator of hypotonicity-induced NLRP3 inflammasome activation, distinct from DAMP-induced activation.
bioRxiv · Jun 11, 2020Immunology