A. D. Adamson

CD163 and Tim-4 identify resident intestinal macrophages across sub-tissular regions that are spatially regulated by TGF-β

The paper identifies CD163 and Tim-4 as markers for intestinal macrophages and shows TGF-β regulates their spatial distribution in different niches.

Allergen-induced airway matrix remodelling in mice can be prevented or reversed by targeting chitinase-like proteins.

This study shows that targeting chitinase-like proteins can prevent or reverse allergen-induced airway matrix remodelling in mice, independent of ongoing inflammation.

Overexpression of IkappaBalpha modulates NF-kappaB activation of inflammatory target gene expression

This study shows that overexpression of IκBα reduces inflammatory gene expression by inhibiting p65 promoter binding, even when p65 dynamics remain intact.

HES1 protein oscillations are necessary for neural stem cells to exit from quiescence

This study shows that HES1 protein oscillations are necessary for neural stem cells to exit quiescence, while sustained HES1 expression does not affect entry into quiescence.

NLRP3 activation in response to disrupted endocytic traffic

This study shows NLRP3 detects disrupted endosome trafficking, leading to inflammasome activation and cytokine release in macrophages.

LRRC8A regulates hypotonicity-induced NLRP3 inflammasome activation

This study identifies LRRC8A as a key regulator of hypotonicity-induced NLRP3 inflammasome activation, distinct from DAMP-induced activation.