Author

R. Buffenstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Ecology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:benchmark study· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:ecology & biodiversity· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. Smith· 2 shared A. Shepard· 1 shared A. T. Ireland· 1 shared A. Ventura· 1 shared B. Martin-McNulty· 1 shared C. A. Rodriguez-Wagner· 1 shared C. Crish· 1 shared C. Ramanathan· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersEcology

M. Smith

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An autochthonous model of lung cancer in the Naked Mole-Rat (Heterocephalus glaber)

J. Kissil, A. Shepard, S. Troutman, S. Hoxha, D. Lester, W. Khaled, E. S. J. Smith, T. Park, R. Buffenstein, D. Dongliang, M. S. J. Teng, C. Crish, K. Tsai, E. Flores, A. Ventura

This study develops an endogenous lung cancer model in naked mole-rats, showing tumor initiation more closely resembles human tumors than in mice.

bioRxiv · Aug 28, 2023Cancer Biology

Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age

J. G. Ruby, M. Smith, R. Buffenstein

The paper reanalyzes naked mole-rat mortality data, confirms previous findings that mortality rates do not increase with age, and compares them to related mole-rat species.

bioRxiv · Mar 27, 2023Ecology

Naked mole-rat and Damaraland mole-rat exhibit lower respiration in mitochondria, cellular and organismal levels

K. N. Yap, H. S. Wong, C. Ramanathan, C. A. Rodriguez-Wagner, M. D. Roberts, D. A. Freeman, R. Buffenstein, Y. Zhang

This study compares bioenergetic properties across mole-rats and comparator species, finding lower respiration and reliance on glycolysis in mole-rats linked to longevity.

bioRxiv · Aug 5, 2021Physiology

Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity

H. G. Hilton, N. D. Rubinstein, P. Janki, A. T. Ireland, N. Bernstein, K. M. Wright, D. Finkle, B. Martin-McNulty, M. Roy, M. Smith, D. M. Imai, V. Jojic, R. Buffenstein

This study uses single-cell transcriptomics to analyze the immune system of naked mole-rats, revealing unique features like a high myeloid-to-lymphoid ratio and absence of natural killer cells.

bioRxiv · Apr 4, 2019Immunology