Author

W. Khaled

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

E. S. J. Smith· 3 shared F. Hadi· 2 shared Y. Kulaberoglu· 2 shared A. Goncalves· 1 shared A. Lonsdorf· 1 shared A. Shepard· 1 shared A. Ventura· 1 shared A.-J. Twigger· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersCancer Biology

E. S. J. Smith

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Regenerative cell turnover coupled to a tumor-hostile niche protects naked mole-rats from cancer

M. Behm, P. Baeza-Centurion, S. Weser, V. F. Busa, P. Zafferani, L. Penso-Dolfin, F. J. Botey, S. Delaunay, N. Hirschmuller, B. Berthet, M.-L. Koch, S. Del Prete, M. Bekavac, D. Sohn, L. Penteskoufi, , M. Frye

This study identifies a tumor-suppressive strategy in naked mole-rats that couples regenerative cell turnover with a tumor-hostile stromal niche to prevent cancer.

bioRxiv · Oct 10, 2023 · PreprintCancer Biology

An autochthonous model of lung cancer in the Naked Mole-Rat (Heterocephalus glaber)

J. Kissil, A. Shepard, S. Troutman, S. Hoxha, D. Lester, W. Khaled, E. S. J. Smith, T. Park, R. Buffenstein, D. Dongliang, M. S. J. Teng, C. Crish, K. Tsai, E. Flores, A. Ventura

This study develops an endogenous lung cancer model in naked mole-rats, showing tumor initiation more closely resembles human tumors than in mice.

bioRxiv · Aug 28, 2023Cancer Biology

Transcriptional changes in the mammary gland during lactation revealed by single cell sequencing of cells from human milk

A.-J. Twigger, L. K. Engelbrecht, K. Bach, I. Schultz-Pernice, S. Petricca, C. H. Scheel, W. Khaled

This study uses single-cell RNA sequencing to analyze mammary epithelial cells from human milk and non-lactating breast tissue, identifying distinct luminal cell clusters and their functional differences during lactation.

bioRxiv · Nov 6, 2020Cell Biology

The material properties of naked mole-rat hyaluronan

Y. Kulaberoglu, B. Bhushan, F. Hadi, S. Chakrabarti, W. Khaled, K. Rankin, E. St. John Smith, D. Frankel

This study investigates the structural and material properties of hyaluronan from naked mole-rats, revealing unique folded structures and gel-forming capabilities that may contribute to their cancer resistance and skin elasticity.

bioRxiv · Jan 8, 2019Biophysics

Naked Mole-Rat Cells are Susceptible to Malignant Transformation by SV40LT and Oncogenic Ras

F. Hadi, Y. Kulaberoglu, K. Lazarus, P. Beattie, E. S. J. Smith, W. Khaled

This study shows that NMR cells can be transformed by SV40LT and HRAS, contradicting previous findings and suggesting non-cell autonomous mechanisms underlie NMR cancer resistance.

bioRxiv · Aug 30, 2018 · PreprintCancer Biology