DNA demethylation switches the drivers of Foxp3 expression to maintain regulatory T cell identity
J. Li, B. Xu, X. Zong, M. He, Y. Fan, R. Cross, J. H. Hanna, Y. Feng
The paper shows DNA demethylation of Foxp3 enhancer CNS2 switches transcriptional drivers to maintain Treg identity by stabilizing Foxp3 expression.
bioRxiv · Dec 16, 2020Immunology