The Small GTPase Rab7 Regulates Release of Mitochondria in Extracellular Vesicles in Response to Lysosomal Dysfunction
W. Liang, R. Diao, J. Quiles, R. Najor, L. Chi, B. Woodall, L. Leon, J. Duran, D. Cauvi, A. De Maio, E. Adler, A. B. Gustafsson
The paper shows that Rab7 regulates mitochondrial release in extracellular vesicles when lysosomal function is impaired, and this process occurs in cardiac pathophysiology.
bioRxiv · Feb 11, 2023 · PreprintPhysiology