L. Meng

Genome-resolved year-round dynamics reveal a broad range of giant virus microdiversity

This study analyzes giant virus dynamics using metagenomic data, revealing year-round recovery and distinct population dynamics linked to microdiversity and niche breadth.

Spatiotemporal dynamics revealed the dark water community of giant virus from a deep freshwater lake

This study uses long-read metagenomics to reconstruct giant virus genomes from a freshwater lake, revealing new species and ecological roles in different water depths.

Deciphering the molecular mechanism underlying morphology transition in two-component DNA-protein cophase separation

The paper investigates DNA-protein co-condensates, identifying two morphology transitions and growth dynamics governed by DNA-p53 interaction strength.

Eukaryotic genomic data uncover an extensive host range of mirusviruses

This study identifies mirusvirus markers in eukaryotic genomes, revealing a broader host range and greater diversity than previously known.

Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathway

This study identifies Akkermansia muciniphila as a key strain in fecal microbiota transplantation that alleviates gut barrier injury by modulating the Wnt/β-catenin signaling pathway in an ETEC infection model.

Gene transfer among viruses substantially contributes to gene gain of giant viruses

The paper investigates viral horizontal gene transfer (vHGT) among nucleocytoviruses and finds it accounts for 28% to 42% of gene gain events in each viral order.

Chronic high-sugar diet in adulthood protects Caenorhabditis elegans from 6-OHDA induced dopaminergic neurodegeneration

This study shows that chronic high-sugar diets in adult C. elegans protect against 6-OHDA-induced dopaminergic neurodegeneration without altering baseline energy metabolism.

Ripening, bursting, and synchronization of biomolecular condensates in a heterogeneous elastic medium

This paper introduces a novel simulation method to model biomolecular condensate dynamics in chromatin, revealing unique scaling behaviors and synchronization phenomena.

A 1.5 Mb continuous endogenous viral region in the arbuscular mycorrhizal fungus Rhizophagus irregularis

The paper identifies a 1.5 Mb viral region in Rhizophagus irregularis, suggesting recent infection by a dsDNA virus.

Genomic adaptation of giant viruses in polar oceans

This study investigates how giant viruses adapt to polar ocean environments by analyzing their biogeography and functional genes, finding that their adaptation is independent of host adaptation.

The Cation/H+ exchanger OsCAX2 is involved in cadmium tolerance and accumulation through vacuolar sequestration in rice

This study identifies OsCAX2 as a key gene for cadmium tolerance and accumulation in rice by promoting vacuolar sequestration, reducing grain cadmium levels by over 70%.

Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation

This study investigates how chromatin-modifying enzymes influence nuclear size and shape during lineage differentiation and cancer, finding that their disruption affects cell fate and nuclear morphology.

Activation of the chemokine receptor CCR1 and preferential recruitment of Gαi suppress RSV replication: implications for developing novel RSV treatment strategies

This study shows that CCR1 activation on respiratory epithelial cells suppresses RSV replication via Gi-mediated inhibition of STAT3 phosphorylation and HSP90 activity, independent of IFN-I.

Elasticity generates indissoluble biomolecular condensates

This study shows elasticity prevents biomolecular condensates from dissolving by establishing a mechanical equilibrium and predicting a phase diagram for indissolubility.

Plankton-infecting relatives of herpesviruses clarify the evolutionary trajectory of giant viruses

The paper identifies plankton-infecting herpesvirus relatives in marine environments, revealing a new viral phylum with evolutionary links to both herpesviruses and giant viruses.

Augmenting Neutralization breadth against Diverse HIV-1 by increasing the Ab-Ag interface on V2

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

Teaching Python for Data Science: Collaborative development of a modular & interactive curriculum

The paper describes the development of an open-source, modular Python data science curriculum for high school women using Jupyter notebooks and collaborative practices.

Neuromodulation of Behavioral Specialization: Tachykinin Signaling Inhibits Task-Specific Behavioral Responsiveness in Honeybee Workers

This study identifies tachykinin peptides as regulators of task-specific behavioral responsiveness in honeybee workers by manipulating their expression and observing behavioral outcomes.

Quantitative assessment of NCLDV-host interactions predicted by co-occurrence analyses

This study uses co-occurrence analyses to predict NCLDV hosts from Tara Oceans data, showing improved performance with a phylogeny-informed method.

Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

Engineering of Chimeric Antigen Receptor T Cells with integrin αEβ7 Results in Augmented Therapeutic Efficacy against E-cadherin positive tumor

This study shows that engineering CAR-T cells with CD103 improves their anti-tumor efficacy against E-cadherin positive tumors by enhancing infiltration, expansion, and persistence in vivo.

High resolution single-cell chromatin 3D modeling reveals coherent chromatin aggregation with varied structures in controlling genome function stability

The paper develops a method to model high-resolution 3D chromatin structures from single-cell Hi-C data, revealing that protein-marked loci aggregate coherently to regulate gene activation across cells.

CTCF-mediated Chromatin Structures Dictate the Spatio-temporal Propagation of Replication Foci

The paper visualizes replication foci during S-phase and reveals a CTCF-dependent hierarchical radial propagation pattern that reverses directionality over time.

Temporal modulation of host aerobic glycolysis determines the outcome of M. marinum infection

This study shows that pre-infection modulation of host glycolysis with 2-DG enhances resistance to M. marinum infection by reducing phagocytosis and bacterial proliferation.

The Expression of Inflammatory Genes in 3T3-L1 Adipocytes Exhibits a Memory to Stimulation by Macrophage Secretions

This study shows that 3T3-L1 adipocytes retain a memory of macrophage secretions, leading to enhanced cytokine expression upon repeated stimulation.

From 1D sequence to 3D chromatin dynamics and cellular functions: a phase separation perspective

The paper identifies forest and prairie genomic domains based on CpG island density and shows their role in shaping cell-type-specific chromatin structures and genomic properties through phase separation mechanisms.

DNA Methylation Landscape Reflects the Spatial Organization of Chromatin in Different Cells

The paper shows DNA methylation's long-range and local correlations reflect chromatin spatial organization across different cell types.

Structural Modeling of Chromatin Integrates Genome Features and Reveals Chromosome Folding Principle

The paper constructs 3D chromatin structures from Hi-C data and shows how chromatin compartments A and B are defined by distinct domain types with different loop sizes and contact patterns.