L. Chi

Sex-specific effects of gut microbiome on shaping bile acid metabolism

This study investigates sex-specific effects of gut microbiome on bile acid metabolism by transplanting feces from male and female mice and measuring bile acid profiles and gene expression.

The Small GTPase Rab7 Regulates Release of Mitochondria in Extracellular Vesicles in Response to Lysosomal Dysfunction

The paper shows that Rab7 regulates mitochondrial release in extracellular vesicles when lysosomal function is impaired, and this process occurs in cardiac pathophysiology.

Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production

This study shows that ITGB4 in airway epithelial cells reduces CCL17 production, thereby suppressing Th2 responses and allergic inflammation in asthma.

Specific activation of HIV-1 from monocytic reservoir cells by bromodomain inhibitor in humanized mice in vivo

This study shows that the bromodomain inhibitor I-BET151 activates HIV-1 transcription in monocytic cells but not CD4+ T cells under cART in humanized mice.