Author

R. E. Georgescu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Assay:cryo-EM· 1 Assay:structural biology· 1

Frequent Co-Authors

M. E. O'Donnell· 4 shared N. Y. Yao· 4 shared F. Zheng· 3 shared H. Li· 3 shared D. Zhang· 1 shared G. D. Schauer· 1 shared L. D. Langston· 1 shared O. Yurieva· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 26 mutual co-author links

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4 shared papersBiochemistry

M. E. O'Donnell

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4 papers

Recent·Most cited

BiochemistrybioRxivMay 3, 2023

Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology

F. Zheng, R. E. Georgescu, N. Y. Yao…·H. Li

This paper reports high-resolution structures of Rad24-RFC loading 9-1-1 onto DNA gaps, showing preference for ssDNA gaps and revealing a unique mechanism for clamp loading and DNA repair.

DOI 10.1016/j.celrep.2023.112694

structural biologyexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivFeb 4, 2022

Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair

F. Zheng, R. E. Georgescu, N. Y. Yao…·M. E. O'Donnell

DOI 10.7554/elife.77469

cryo-EMexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintOct 1, 2021

Rad24-RFC loads the 9-1-1 clamp by inserting DNA from the top of a wide-open ring, opposite the mechanism of RFC/PCNA

F. Zheng, R. E. Georgescu, N. Y. Yao…·H. Li

This paper reveals the mechanism by which Rad24-RFC loads the 9-1-1 clamp onto DNA by inserting ssDNA from the top of an open ring, differing from RFC/PCNA loading.

DOI 10.1101/2021.10.01.462756

experimental assay

𝕏 PostBluesky

BiochemistrybioRxivJun 6, 2017

Mcm10 functions to isomerize CMG-DNA for replisome bypass of DNA blocks

L. D. Langston, R. Mayle, G. D. Schauer…·M. E. O'Donnell

This study shows Mcm10 enables CMG helicase to bypass DNA blocks on the non-tracking strand by isomerizing the CMG-DNA complex.

DOI 10.7554/elife.29118

experimental assaychromatin & epigenetic regulation

𝕏 PostBluesky