R. Flaumenhaft

Shear-Mediated Platelet Microparticles Demonstrate Phenotypic Heterogeneity as to Morphology, Receptor Distribution, and Hemostatic Function

This study shows that shear stress generates platelet-derived microparticles (PDMPs) with varied morphology and receptor expression, which both enhance thrombin generation and inhibit platelet aggregation.

Engineered high-density lipoprotein particles that chaperone bioactive lipid mediators to combat endothelial dysfunction and thromboinflammation

This paper constructs engineered HDL-like particles that chaperone bioactive lipids to reduce inflammation and endothelial dysfunction.

The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation

This study identifies VLK as a secreted tyrosine kinase essential for platelet activation and thrombus formation by analyzing its role in phosphorylation and signaling.

Reduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles

This study uses smFRET to show PDI adopts three conformational ensembles, with redox state affecting their population and exchange rates.