Redefining Interleukin 11 as a regeneration-limiting hepatotoxin
A. A. Widjaja, J. R. Dong, E. Adami, S. Viswanathan, B. NG, B. K. Singh, W.-W. Lim, J. Zhou, L. S. Pakkiri, S. G. Shekeran, J. Tan, S. Y. Lim, M. Wang, R. Holgate, A. Hearn, , S. A. Cook
This study reveals IL11 as a hepatotoxin that limits liver regeneration after APAP overdose, showing its inhibition of endogenous IL11 activity protects mice.
bioRxiv · Nov 4, 2019Physiology