Author

B. Ng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Immunology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

S. A. Cook· 3 shared S. Schafer· 3 shared S. Viswanathan· 3 shared W.-W. Lim· 3 shared A. A. Widjaja· 2 shared E. Adami· 2 shared J. Tan· 2 shared M. Wang· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

S. A. Cook

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mathematical model of intestinal lipolysis of a long-chain triglyceride

O. Rezhdo, R. West, M. Kim, B. Ng, S. Saphier, R. L. Carrier

This paper develops a kinetic model to predict triglyceride digestion in the intestine, showing it aligns with experimental data and outperforms simpler models.

bioRxiv · May 1, 2024 · PreprintBioengineering

Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration

B. Ng, K. Y. Huang, C. J. Pua, W.-W. Lim, F. Kuthubudeen, A. A. Hii, S. Viswanathan, E. G. Petretto, S. A. Cook

This study shows IL11 impairs AT2 cell differentiation into AT1 cells and blocks lung regeneration in mice and humans.

bioRxiv · Nov 11, 2022Immunology

Redefining Interleukin 11 as a regeneration-limiting hepatotoxin

A. A. Widjaja, J. R. Dong, E. Adami, S. Viswanathan, B. NG, B. K. Singh, W.-W. Lim, J. Zhou, L. S. Pakkiri, S. G. Shekeran, J. Tan, S. Y. Lim, M. Wang, R. Holgate, A. Hearn, , S. A. Cook

This study reveals IL11 as a hepatotoxin that limits liver regeneration after APAP overdose, showing its inhibition of endogenous IL11 activity protects mice.

bioRxiv · Nov 4, 2019Physiology

Fibroblast-specific IL11 signaling is required for lung fibrosis and inflammation

B. Ng, J. Dong, S. Viswanathan, A. A. Widjaja, B. S. Paleja, E. Adami, N. S. J. Ko, M. Wang, S. Lim, J. Tan, S. P. Chothani, S. Albani, S. Schafer, S. A. Cook

This study shows that fibroblast-specific IL11 signaling is critical for lung fibrosis and that inflammation can result from stromal activation rather than being a primary driver.

bioRxiv · Oct 11, 2019Cell Biology

Interleukin 11 expression causes murine inflammatory bowel disease

W.-W. Lim, B. Ng, A. Widjaja, C. Xie, L. Su, N. Ko, S.-Y. Lim, X.-Y. Kwek, S. Lim, S. Cook, S. Schafer

This study shows that IL11 secretion from stromal cells drives inflammatory bowel disease in mice, suggesting IL11 as a therapeutic target for inflammatory bowel disease.

bioRxiv · Sep 5, 2019Pathology