Cellular selectivity of STING stimulation determines priming of tumor-specific T cell responses
B. Jneid, A. Bochnakian, F. Delisle, E. Djacoto, J. Denizeau, C. Sedlik, F. Fiore, R. Kramer, I. Walters, S. Carlioz, B. Malissen, E. Piaggio, N. Manel
This study shows that targeting STING in dendritic cells with cGAMP-VLP enhances tumor-specific T cell responses and synergizes with PD1 blockade for tumor eradication, while synthetic CDN causes systemic T cell activation without specific T cell differentiation.
bioRxiv · Dec 1, 2021Immunology